| Tamofen for the Treatment
of Female Infertility |
 |
| Tamofen versus
Clomiphene |
|
 |
Tamofen is preferential to clomiphne in
treating infertile women with deficient post
coital test. (1)
|
|
Tamofen is better than clomiphene for ovulation
induction in women with poor cervical mucus
quality. (2) |
| |
|
| |
| |
Clomiphene |
Tamofen |
| 17 ß-estradiol |
Increased |
Significantly
increased |
| PH of endocervical mucus |
Decreased |
No change |
| Spermoatozoa penetration metre score
improvement |
No change |
Significantly
increased |
| Cervical mucus improvement |
No change |
Significantly
increased |
N=22 (1) |
|
 |
| |
Improves
the total Cervical Score (3) |
|
| |
Achieves
satisfactory pregnancy rate, no side effects and
fewer treatment cycles (3) |
|
 |
|
| Composition: |
|
| Each scored tablet contains Tamoxifen
citrate equivalent to 10 mg Tamoxifen. |
|
|
| Indications: |
|
|
Anovulatory female infertility: |
| |
In women with regular menstrual
cycles:
20 mg daily for 5 successive days starting
the second day of menstruation. If ovulation
is not achieved, further courses may be
given in subsequent cycles with increasing
the daily dose to 40 mg then 80 mg per day.
In case of amenorrhea or irregular
menstrual cycles:
The treatment course is started any day
for 5 successive days, and if ovulation
is not acheived, the course is repeated
with a higher dose - as mentioned above
- afte a 45-day interval.
(Pregnancy
should be excluded before starting therapy)
N.B. The daily doses could be given in two
divided doses. |
|
Idiopathic oligospermia: |
| |
20 mg daily. Since spermatogenesis and full
sperm maturation take in average 3 months-treatment,
results will not appear before a similar period.
The usual treatment course is 2 years, or
until pregnancy is achieved. |
|
|
|
| Dosage: |
|
|
Anovulatory female infertility. |
|
Idiopathic oligospermia. |
|
|
|
| Side
Effects: |
|
| Tamoxifen is very well
tolerated and side effects are unusual. However
hot flushes and mild gastrointestinal intolerance,
have been rarely reported in females. |
|
|
| Contra-Indications: |
|
| Pregnancy - Hypersensitivity
to tamoxifen. |
|
|
| How
Supplied: |
|
| Boxes of 30 scored tablets. |
|
|
| References: |
|
| 1. |
Frans JME Roumen,
M.D.; “Treatment of infertile
women with a deficient postcoital test with
two antiestrogens: Clomiphene and Tamoxifen”
Fertility & Sterility Vol.(41)
No 2, Feb. 1984. |
| 2. |
Annapurna V etal. “Effect
of two antiestrogens, Clomiphene citrate &
Tamoxifen, on cervical mucus & sperm-cervical
mucus interaction” Int J Fertile Womens’
Med; 42(3): 215-218; May 1997. |
| 3. |
Tamoxifen treatment in women with
failure of clomiphene citrate therapy.
Borenstein R etal, Obstet. Gynaecol.
29: 173-175 An 14834; July 1989. |
|
|
|
|
