| Composition: |
 |
| |
Each sustained release
capsule contains 2.5 mg
of Nitroglycerin. |
|
| |
|
| Pharmacokinetics: |
|
| |
Nitrotard is metabolized
in liver. The metabolites
are exerted by the kidney. |
|
| |
|
| Indications: |
|
 |
Chronic angina pectoris. |
|
Heart failure. |
|
| |
|
| Properties
and Mechanism of Action: |
|
|
Nitrotard (nitroglycerin)
is a vasodilator proven
to be the mainstay of therapy
in management of angina
pectoris. It's also used
to treat congestive heart
failure. |
|
Nitrotard (nitroglycerine)
is converted to nitric oxide
which relaxes smooth muscle
cell of vessels. |
|
Nitrotard (nitroglycerine)
induced vasodilation increases
venous capacitance and decreases
arterial resistance, thereby
reducing both the pre-load
and after-load and lowering
the cardiac oxygen demand. |
|
Nitrotard (nitroglycerine)
redistributes blood to ischemic
areas in patients with atherosclerotic
coronary heart disease. |
|
| |
|
| Dosage: |
|
| |
The usual recommended
dose is: one capsule 2.5
mg twice daily, or as prescribed
by the physician. |
|
| |
|
| Contraindications: |
|
|
Hypersensitivity to nitrates. |
|
Shock, collapse. |
|
Recent myocardial infraction. |
|
Obstructive cardiomyopathy. |
|
Increased intracranial
pressure. |
|
Pernicious receiving sildenafil
citrate. |
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| |
|
| Precautions: |
|
|
Nitrate therapy may aggravate
angina caused by hypertrophic
cardiomyopathy. |
|
Use in pregnancy only
if potential benefits outweigh
risks. |
|
| |
|
| Side Effects: |
|
| |
Headache, syncope, flushing,
drug rash, dermatitis and
tolerance may occur. |
|
| |
|
| Pack: |
|
| |
Boxes containing 6 strips,
10 capsule each. |
|
 |
|
