| Acne
Treatment |
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The standard approach for treating acne is
multi-drug therapy.
The combination of erythromycin and benzoyl peroxide
has proven to be well tolerated and effective
topical treatment for acne vulgaris.
Multicenter randomised study in 223 patients with
moderate to moderately severe acne who received
erythromycin /5% benzoyl peroxide or matching
vehicle control for 8 weeks.
Investigators found the combination was more
effective for pustular and papular lesions than
any of the other treatments
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- High efficacy in pustular and papular lesions.
- Fast acting.
- Dual antimicrobial therapy.
- Anti-inflammatory.
- Minimize the antimicrobial resistance.
- Improve patient satisfaction.
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| Pharmacology: |
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Erythromycin is a bacteriostatic macrolide antibiotic,
but it is a bactericidal in high concentration.
Its effect bases on the inhibition of bacterial
protein synthesis.
Although the mechanism by which topical erythromycin
acts in reducing inflammatory lesions of acne
vulgaris is unknown, it is may be due to its antibiotic
action (it works against most G +ve & G –ve
microorganisms)
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| Indication: |
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Topical control of acne vulgaris particularly
inflammatory types with papules & pustules
The topical treatment with erythromycin as alternative
to systemic treatment
Clinical trials the authors Fulton & Pablo
(1974) report :- an improvement of acne after
topical application of erythromycin as well as
a reduced concentration of free fatty acids in
the skin surface lipids.
Moreover aknemycin oint emulsified the sebum
in the acne & remove it from the duct of the
sebaceous gland.
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| Pharmacokinetics: |
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| Absorption |
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After using Akne-mycin 2% sol. to large
areas of forehead, back, shoulder and upper
arm.
Blood samples have been taken before 2 &
4 weeks after. No erythromycin was detected
in the serum 0.3 ug/ml. |
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Aknemycin 2% has significant reduction effect
in the propionibacterium acnes as well as
the number of total germs. |
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| Toxicology |
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Erythromycin is considered one of the best
tolerated antibiotics used in present. |
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Erythromycin is a unique non sensitizing
antibiotic after topical application. |
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| Aknemycin
Range: |
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| Aknemycin oint 2% Pack. 15g
oint |
| For dry sensitive skin |
| Indication of |
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Acne vulgaris all forms particularly inflammatory
forms with papules & pustules. |
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Topical antibiotic for any superficial wounds
or abrasions. |
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| Aknemycin sol 2% in ethanol
Pack. Bottle of 25 ml with applicator |
| For oily skin |
| Note: Ethanol
inforce the antibact. action of erythromycin |
| Indication of |
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Acne vulgaris all forms particularly inflammatory
forms with papules & pustules. |
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Topical antibiotic after shave as a prophylactic
to any dermatological infection. |
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| Efficacy: |
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Highly effective against propionibacter acnes
& all other microorganisms such as:
Staphylococci - streptococci
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Safety:
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Well tolerated considered the best tolerated
antibiotic.
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| Contraindications: |
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Hypersensitivity to erythromycin or to any component
of these product.
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| Precautions: |
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for external use only. Keep away from eyes, nose, mouth & other mucous
membranes.
Super infection: Use of antibiotics
(especially prolonged or repeated therapy)
may result in bacterial or fungal overgrowth
of non susceptible organisms.
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| Adverse
reactions: |
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Erythema, desquamation, burning sensation rarely.
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| Patient
information: |
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Wash, rinse and dry affected areas before application.
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| Administration
and Dosage: |
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Apply morning & evening to affected areas
before applying, wash, rinse & dry all areas
to be treated.
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