The standard approach for treating acne is
multi-drug therapy.
The combination of erythromycin and benzoyl peroxide
has proven to be well tolerated and effective
topical treatment for acne vulgaris.
Multicenter randomised study in 223 patients with
moderate to moderately severe acne who received
erythromycin /5% benzoyl peroxide or matching
vehicle control for 8 weeks.
Investigators found the combination was more
effective for pustular and papular lesions than
any of the other treatments
High efficacy in pustular and papular lesions.
Fast acting.
Dual antimicrobial therapy.
Anti-inflammatory.
Minimize the antimicrobial resistance.
Improve patient satisfaction.
Indications:
Acne: mild to moderate acne vulgaris inflammatory
&noninflammatory & oily skin.
May be used in more severe cases as in therapeutic
regimens. (Akne-mycin + Akneroxide)
Akneroxide 5 gel is applied once to twice
daily. Improvement of the treated condition depends
on degree & type of acne, frequency of products
use & nature of other therapies.
Contraindications:
Hypersensitivity to benzoyl peroxide.
Precautions:
External use only. Avoid contact with eyelids,
lips, mucous membranes.
Bleaching effect. Benzoyl peroxide is an
oxidizing agent; it may bleach hair and colored
fabric.
Avoid sun & other irritating factors
(photosensitivity).
Drug interaction:
Tretinoin: concomitant use may cause significant
skin irritation.
Side Effects:
Slight irritation of the skin and may be redness.
Properties:
Long lasting antibacterial effect:
Which extends to propionibacterium acnes, which
is the etiopathogenic organism of acne
Effective also against other organism in the
follicular region.
A keratolytic and comedolytic:
Antibloking effect to the follicular orifices
& reduction in the comedo count of the skin
(keratolytic effect similar to that of salicylic
acid when compared under the scan electron microscope.)
A sebostatic effect:
This antiseborrheic effect, leads to a lessening
of the sebum secretion
- In addition, the fatty acids are reduced,
as a contact of sebum.
