Miconazole is a broad spectrum fungicidal
drug as it acts against most Dermatophyte
species, Candida species and Pityriasis versicolor.
Bactericidal action against Staphylococci.
& Streptococci (Gram positive bacteria)
Mechanism
of Action
Inhibition of ergosterol biosynthesis,
which leads to altering the cell wall permeability
and loss of essential intracellular elements.
Inhibition of oxidative and per-oxidative
enzyme activity leading to fungal cell necrosis
& death due to accumulation of toxic concentrations
of hydrogen peroxide.
Pharmacokinetics
No reports indicate that Miconazole nitrate
is absorbed systemically following application
to intact skin.
Negligible traces of miconazole are absorbed
and metabolized in the liver into inactive
metabolites, then excreted in urine and feces.
Indications
Topical treatment of cutaneous
moniliasis (candidiasis) caused by Candida
albicans e.g paronychia and onychomycosis
in combination with a systemic antifungal.
Topical treatment of dermatophytes (ringworm)
: Tinea Corporis - Tinea Cruris – Tinea
Pedis - Tinea Capitis.
Topical treatment of Pityriasis versicolor
(Tinea Versicolor).
Mixed fungal and bacterial infections e.g
diaper dermatitis.
Administration
& Dosage
Apply to affected area:
Twice Daily (Morning & Evening) for
All Types of Skin Fungal Infections.
Once Daily for Tinea Versicolor
Duration of Treatment
3-4 Week-Treatment in Tinea Versicolor
(patients with tinea versicolor usually exhibit
clinical & mycological clearing in 2 weeks.
2 Week-Treatment in Tinea Cruris, Tinea
Corporis & candidiasis.
1 Month-Treatment in Tinea Pedis.
Remarks
Continue the same treatment for one more
week after the full recovery to prevent relapses.
Early relief of symptoms (2 to 3 days) occurs
in most patients.
Clinical improvement is seen fairly soon
after treatment.
Adverse
Reactions
Miconaz is well tolerated when applied
topically.
Local irritation or hypersensitivity reactions
may rarely occur.
How Supplied
Cream: Tube of 20g
Powder: Dusters of 20g
Why You
Should Use Miconaz?
Broad-spectrum Fungicidal and Bactericidal,
highly effective in both fungal and mixed
fungal-bacterial infections.
Miconazole Efficacy is well-established
and proven overtime.
1. High cure rates (> 95%).
2. Acquired resistance is rare.
3. Quick relief of infection
Miconazole Tolerability is time-tested
Use Cream in:
Any cutaneous or muco-cutaneous Fungal
infection of (e.g. candidiasis, dermatophytosis,
pityriasis versicolor).
Fungal infections of the hair and nail,
in combination with an oral antifungal.
Bacterial and mixed fungal-bacterial infections
caused by Gram positive bacteria (e.g. Staphyllococci
& Streptococci) e.g. impetigo, folliculitis,
etc…
Use Powder in:
Tinea Pedis : Between toes and inside socks.
Candidiasis and dermatophytosis of inter-trigonous
areas (skin folds), such as under the breasts
or axillae, to avoid maceration of the skin.
