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The active ingredient
in Enemacort is Budesonide.
A glucocorticosteroid that modified
to have powerful local anti-inflammatory
activity, with low systemic effect. |
|
Very low intestinal
absorption (only <10%)
This little fraction of the absorbed
budesonide is extensively biotransformed
in the liver (first pass metabolism
90%). |
|
The isotonic aqueous
vehicle contains carboxymethyl cellulose. |
|
The surface active properties
of that vehicle distinguish this product
from other drugs used by the same
route of administration. |
| |
- By virtue of its surface activity,
carboxymethyl cellulose ensures
rapid spread ability of the retention
enema and helps carrying the microniszed
particles of the budesonide against
gravity to reach higher lesions
in the colon.
|
|
Carboxymethyl cellulose
provides muco-adhesive character to
the drug. |
| |
- And directing the active ingredient
to adhere to the ulcerated mucosa.
- Maximizing the retention of
the drug on the affected site
even with expulsion of the liquid
phase.
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