About Us Careers HOME >>
 
Home > Products > Gastroenterology > Ranitidine> More Info.
DOSAGE And INDICATIONS:
Ranitidine is indicated for the treatment of duodenal ulcers, benign gastric ulcer including prevention of duodenal ulceration associated with non-steroidal anti-inflammatory agents, reflux oesophagitis and the Zollinger-Ellison syndrome. To minimise the consequences of acids-aspiration syndrome during anaesthesia, ranitidine is used as premedication to reduce volume and acid content of gastric secretion.
CONTRA-INDICATIONS:
Any known hypersensitivity to any of the ingredients. Safety during pregnancy and lactation has not been established. Patients with a known history of porphyria should avoid taking RANITIDINE.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:

Side-effects:
- Transient and reversible changes in liver functions.
- Occasional reports of reversible hepatitis without jaundice (hepatocellular, hepatocanicular or mixed).
- Blood count changes (leucopenia, thrombocytopenia)
- Agranulocytosis or pancytopaenia with marrow hypoplasia or aplasia have been reported with the longterm use.

In some few cases:
- Constipation, diarrhoea, nausea and vomiting.
- Skin rash, including cases of erythema multiforme.
- Acute pancreatitis, arthralgia and myalgia.

Special Precautions :

Where a gastric ulcer is present, the possibility of malignancy should be excluded before treating a patient with a H2-antagonist, for it may mask the symptoms of carcinoma in the stomach and therefore delay diagnosis of the condition.

Patients with severe renal impairment will have increased and prolonged plasma levels of ranitidine (ranitidine is excreted via the kidney) therefore it is advised to reduce the dosage to 150 mg daily.

Ongoing monitoring of patients on long term treatment of RANITIDINE is necessary to safeguard against unforeseeable consequences of the medicine.
Elderly patients who are taking a combination of RANITIDINE and non-steroidal anti-inflammatory agents, should be well monitored.
Site Map  |  Privacy Statement  |  Terms of Use
Copyright © 2002 Medical Union Pharmaceuticals